Prions prefer caveosomes
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چکیده
منابع مشابه
Prions prefer caveosomes
Prions prefer caveosomes he story of prions gets increasingly bizarre. The peculiar pathogenicity of prion protein (PrP) makes understanding and treating the resulting diseases difficult. Now, on page 703, Peters et al. provide evidence that PrP also uses an unusual endocytic pathway en route to lysosomes. The harmless version of PrP is processed and directed to caveolin-rich glycolipid rafts a...
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Endocytosis of various endogenous plasma membrane molecules, including signalling receptors, glycosphingolipids and glycosylphosphatidylinositol (GPI)-linked proteins, occurs in the absence of functional clathrin-coated pits. Most of these molecules are found in biochemically defined lipid rafts, which suggests that at least some clathrin-independent endocytosis may be raft specific or raft med...
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The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transforming bacteria (Avery et al. 1944). Four decades later, the discovery that a protein could mimic viral and bacterial pathogens with respect to the ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1624iti1